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Medarex, Inc.

Phase II clinical trial with MDX-070 in prostate cancer announced

Published in Pharma Investments, Ventures and Law Weekly, July 25th, 2004

Medarex, Inc., (MEDX) announced the initiation of a multidose, dose-escalation, phase II, clinical trial of MDX-070, a fully human antibody to prostate specific membrane antigen (PSMA), for patients with hormone refractory prostate cancer.

The phase II clinical trial is expected to enroll up to 30 patients with prostate cancer. Patients are expected to receive four biweekly doses of 1, 5, or 10 mg/kg of MDX-070 and will be assessed for tumor response based on objective tumor response and decrease in prostate specific antigen serum levels.

In the single-dose, phase I, clinical study in 18 patients with metastatic prostate cancer, the antibody was...

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