Purdue University

Virus known for its photo ops makes its movie screen debut

Published in Pharma Investments, Ventures and Law Weekly, September 19th, 2004

High-resolution snapshots of a virus attacking its host - which have culminated in a movie of the process - could reveal secrets of viral infection and improve gene therapy techniques, according to a Purdue University research group.

Structural biologists including Michael G. Rossmann have obtained clearer pictures of how the T4 virus, long known to infect Escherichia coli bacteria, alters its shape as it prepares to pierce its host's cell membrane. The complicated infection process requires a flower-like section of the virus, known as the baseplate, to shape-shift by dramatically changing the configuration of the numerous proteins that form it. The team has...

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Source: Pharma Investments, Ventures and Law Weekly (2004-09-19)

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