Genentech, Inc.
Novel role found for osteoprotegerin ligand in monocyte effector function
Published in Pharma Investments, Ventures and Law Weekly, September 19th, 2004
"Osteoprotegerin Ligand (OPGL) is a member of the tumor necrosis factor ligand superfamily and has been shown to be involved in interactions between T cells and dendritic cells. Its role in monocyte effector function, however, has not been defined. In the present study a role for OPGL in activating monocytes/macrophages has been characterized," scientists in the United States report.
"OPGL was found to up-regulate receptor activator of NF-kappaB (RANK) receptor expression on monocytes, regulate their effector function...
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