INSERM U513, Creteil
Genetic background holds sway over phenotypic activity in the nervous system
Published in Pharma Investments, Ventures and Law Weekly, September 19th, 2004
According to published research from France, "the dopamine transporter (DAT) plays a critical role in calibrating the duration and intensity of dopamine (DA) neurotransmission. Mice in which the DAT gene has been genetically deleted exhibit constitutively high levels of extrasynaptic DA and spontaneous hyperactivity. Numerous studies have characterized the adaptive molecular, physiological, and behavioral consequences of abnormal DA neurotransmission in these mice."
"In order to determine the genetic background contribution to these phenotypes, the DAT mutation was...
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