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Pharma Investments, Ventures and Law Weekly

Susan Hasty, Publisher

Table of Contents . . . September 26th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pharma Investments, Ventures and Law Weekly | Other Publications

Advanced Neuromodulation Systems, Inc. - Cyberonics acknowledges purchase of $3.5M shares, shows no interest in merger

Agile Therapeutics - Contraceptive patch maker closes $4.5M financing

Akorn, Inc. - Pharmaceutical firm announces $14.1M private placement

Alchemia Limited - Strong cash reserves and planned Nasdaq listing for Australian biotech company

Align Technology, Inc. - U.S. District Court finds lawsuit challenging digital dentistry patents invalid

Arcadia Services, Inc. - Critical Home Care reports post-acquisition Q1 results, discusses acquisition

AspenBio, Inc. - Biotech firm announces closing on $1,287,500 private placement

BioAlliance Pharma SA - Biopharmaceutical company closes Series C financing

Biophan Technologies, Inc. - Biomedical technology firm reaches milestone in intellectual property

Biosite Incorporated - Diagnostics firm reports new option grants

Biosyntech - Biotechnology company releases first quarter financial results

Biota Holdings Limited - Drug discovery company announces 8% revenue growth over prior year

Biovail Corporation - Pharmaceutical firm announces stock trades

Business Update - Boston Scientific stent regains market share, despite August sales

China Pharmaceuticals Corp. - China-based pharmaceutical reports increased revenues

- Former Senator Bob Dole announces growth in use of new Medicare Drug Discount card

Abo Akad University, Turku - Sol-gel-derived titania coating promotes direct soft tissue attachment

Advanced Neuromodulation Systems, Inc. - Device maker announces 14.9% equity stake in Cyberonics

Albert Einstein College of Medicine - Resistin plays a physiological role in hepatic insulin resistance

Amedica Corporation - Orthopedic device firm hires Bryan McEntire as VP, manufacturing

American Gastroenterological Association - Virtual colonoscopy shows significant promise, though some issues unresolved

Ankara University - Australian researchers report first case of unusual cancer

Applera Corporation - Hunkapiller retires from research tools company

Archet Hospital, Nice - Imatinib mesylate lowers VEGF levels in chronic myeloid leukemia patients

Arizona State University - Aerobic fitness associated with increased recovery of exercise-related hormones

Artemis Pharmaceuticals GmbH - Pharmaceutical companies cooperate in mouse genetics

Austin Medical Technologies, Inc. - Contract secured with Eagle Laboratories for eyeDirecti brand

Autonomous University of Madrid - The transcription factors Snail and E47 effect tumor invasion differentially

Avera Mckennan University Hospital - Obesity increases morbidity in kidney transplantation

Avian Influenza - Cats can catch, spread bird flu to other cats; human risk being investigated human

Awards - IDX Announces winners of Carecast Customer Innovation Awards

Bayer Healthcare Wuppertal - Inhibition of PDEs can disturb vision, elevate heart rate and vasodilation

Baylor Intl. Pediatric AIDS Initiative - HIV-positive children in resource-limited setting successfully treated

Best Practices, LLC - Report finds new benchmarks for supply chain centers

BioMarin Pharmaceutical, Inc. - Positive data reported from phase Ib trial of Vibrilase for serious burns

Bioenvision, Inc. - New patient data generated in support of the clofarabine new drug application

Biotronik - First Kronos LV-T ICD implanted in heart failure patient in Germany

Bracco - Early findings suggest Isocolan is effective for constipation during pregnancy

BrainLAB - Companies agree on implant integration

Brigham and Women's Hospital - Bayesian updating methodology suitable for safety analysis

Bristol-Myers Squibb - Long-term data provides guidance on use of Sustiva in HIV treatment

Butler Hospital - ARICEPT may offer hope to those suffering from mild cognitive impairment

CEA/Saclay, Gif-sur-Yvette - H2 O2 does not induce antioxidant defenses in mammals

CHI, Creteil - Airway dysfunction syndrome caused by fire extinguishers

CMS, Inc. - CMS awarded Premier contract

CalbaTech, Inc. - Life sciences firm reports loss of $0.01 per share

California Institute of Technology - Chain receptors define a layer of selectivity in the ubiquitin-proteasome system

Cardarelli General Hospital, Naples - Many questions about AML remain unanswered, and controversy continues

Cardiovascular Care - Untested catheter used in trials of recalled stent

Cedars-Sinai Medical Center - Dendritic cell vaccine elicits antigen-specific T-cells against glioma

Center for Orthopedic Research, Lausanne - Wear particles may contribute to implant loosening

Chiba Institute of Technology - Novel target site for gene therapy may control/manage HIV-1 infection

ChondroGene, Ltd. - ChondroGene reports second-quarter 2004 financial results

Circle Group Holdings, Inc. - New Z-Trim production facility opens

City University of New York - Oral and postoral determinants of food reward outlined

Cornell University - Maternal obesity negatively linked to breastfeeding success in Hispanic women

Correctional Health - Officials say health contract was renewed in midst of jail deaths

CytoGenix, Inc. - Gene-silencing company initiates planned expansion of its scientific staff

DarPharma - DAR-0100 to be evaluated in trial for working memory deficits in schizophrenia

DiagnoCure, Inc. - Diagnostics company achieves second consecutive break-even quarter

Dupont - Facility to produce nonwoven fabrics for healthcare professionals

ECRI - Evidence of wheelchair improvements limited, independent research agency finds

Edwards Lifesciences Corp. - Doctors try to help body grow bypasses

Electric Aquagenics Unlimited, Inc. - Company to beta test empowered water generators at grocery chains

Endovasc, Inc. - Trial data: Liprostin shows promise in wound healing, treating ischemic ulcers

Erasmus MC, Rotterdam - Replication-competent HIV-2 found in patients with undetectable viremia

Eurand - Company receives approval to market generic potassium chloride

European Society of Cardiology - Patients often receive needless treatment

Evanston Northwestern Healthcare - Researchers identify gene associated with susceptibility to schizophrenia

Evident Technologies, Inc. - Nanomaterials company, NIST, enter instrumentation R&D agreement

Florida A&M University - Liposome delivery of monesin overcomes problem of drug resistance

Fundacion Hospital Alcorcon - Postvaccination hepatitis B surface antigenemia explored

GenoMed, Inc. - Genomics company taps Dennis Robbins to chair business advisory board

George Washington University - Exposure to DEHP in neonates doesn't hurt physical or sexual growth

Giessen University - Enzyme signpost points to better bowel cancer test

Gladstone Inst. of Virology & Immunology - Future of HIV therapeutics is brightening, says expert

Glenmark Pharmaceuticals, SA - Company files phase I application for GRC 3886 in the U.K.

Harvard Medical School - Infectious disease early-warning monitoring program free to Internet users

Harvard University - Endovascular stent platelet reactivity is dependent on flow

Hebrew University of Jerusalem - Novel bioelectronic method detects HIV-1 drug resistance

Henry Ford Hospital - Brain stimulating implant returns life to boy with dystonia

Hopital Beaujon, Clichy - Clevudine potent and tolerable in hepatitis B virus-infected patients

Hopital Nord St. Etienne - Real-time PCR sensitive/specific for P. jiroveci from bronchoalveolar lavage

Hopital Sainte-Justine - Genetic syndromes involving obesity reviewed

Hung Kuang University, Tacihung - PCR primer pair based on 16S rDNA detects Salmonella serovars in food samples

Hyogo Medical University - Stress protein ORP150 protects against cerebral I/R injury in mice

IC-MedTech - Novel anti-cancer therapeutic licensed from Summa Health System

INIA, Madrid - Association of FABP3 gene with milk traits in Manchega sheep is studied

INSERM E352, Paris - Vaccine targeting carbohydrate antigen induces tumor-specific antibody

Iams Pet Imaging Center - North Carolina State University opens veterinary medicine imaging center

Imaging Dynamics Company - Florida, Alabama hospitals install IDC Xplorer 1800 Digital Radiography System

Imperial College, London - Review describes major mechanisms of X-linked dilated cardiomyopathy

InKine Pharmaceutical Company, Inc. - Pharmaceutical company appoints vice president of commercial development

Indiana University - Pancreatic enzymes elevated in children with diabetic ketoacidosis

Inha University, Inchon - Lateral plates and screws for cervical fusion are safe

Inst. of Bioeng. & Nanotechnology, Singapore - An ultrasensitive nucleic acid biosensor analyzes genes in nanograms of RNA

Institut Catala d'Oncologia, Barcelona - Hepatitis C virus infection associated with increased risk of malignant lymphoma

Introgen Therapeutics, Inc. - Data: Enhanced tumor cell killing when INGN 241 is used with Herceptin

Jerini AG - Icatibant study in hereditary angioedema concludes with positive results

Johannes-Gutenberg-University - Interferons associate with the onset of thyroid dysfunction

Johns Hopkins Medical Institute - Electroporation improves the transfection of cells in murine wounds

Karolinska Hospital - Glucose abnormalities seen in heart attack patients

Karolinska Institute - Apolipoprotein CIII promotes beta-cell death in type 1 diabetes

Karolinska Institute - Frequent alcohol drinking in middle age harms the brain

Kyushu University, Fukuoka - Tissue adhesive may be a cytokine barrier

L'Hopital Archet, Nice - Screening, care strategies needed for pregnant women with type 2 diabetes

Landeskrankenhaus Feldkirch - Effect of concentric, eccentric muscle training explored

Larissa National Reference Lab. of Brucellosis - Vaccination of sheep and goats lowers human brucellosis prevalence

Live Tissue Connect, Inc. - Consortium reports successful new cancer surgery procedures in clinical trials

Los Alamos National Laboratory - HIV replication rates should vary between cells with different lifespans

Lund University - Efficacy and safety of ximelagatran confirmed for atrial fibrillation patients

M.D. Anderson Cancer Center - Houston researchers examine breast cancer drug Herceptin, try to improve it

META Group, Inc. - Radio frequency ID technology use predicted to increase during next 18 months

Massachusetts Institute of Technology - Work emphasizes need for stronger regulations of herbal drugs

Mayo Clinic - Mayo Clinic pioneers gene therapy delivery system for glaucoma

McGill University - Canadian researchers identify new player in breast cancer

McMaster University, Hamilton - TSLC1 gene induction initiates apoptosis in non-small-cell lung cancer cells

MedPanel - Syndicated study highlights non-small cell lung cancer drug development

Medical College of Georgia - Partnership probes tissue regeneration for reconstructive surgery

Medical University of Vienna - CpG motifs are efficient adjuvants for DNA cancer vaccines

Medstat - High co-payments influence multiple sclerosis patients' medication choices

Meridian Bioscience, Inc. - FDA clears ImmunoCard Toxins A&B rapid test for severe colitis

Meyer Children's Hospital, Haifa - Role of hydroxysteroid dehydrogenase in adiposity regulation investigated

NOW Foods, Inc - Dietary supplement company gets export award from U.S. Department of Commerce

Nanjing Normal University - 5-Azacytidine induces stem cells to differentiate into cardiomyocyte phenotype

National Taiwan University - RBMY gene expression associates with male liver cancer formation

Neurobiological Technologies, Inc. - Drug development company names VP clinical development to lead Viprinex team

New York Medical College - Seizure disorder heightens risk of gastrostomy-related reflux in children

New York University - Modified response sufficient to enhance cognition in Alzheimer disease

Novartis International AG - Pharma company announces results from Prexige trial

Obstetrics - Gap between real vs. perceived risk of postpartum hemorrhage thwarts treatment

Obstetrics - Lymphocyte surface glycoprotein may be indicator of recurrent pregnancy loss

Okayama Medical School - Novel movement checker provides accurate measure of stability

Okayama University - Area postrema neurons highly sensitive to propofol

Orchid BioSciences - Bioscience company provides identity DNA testing services for Kinsearch Registry

Osaka University - Poly (Vinylpyrrolidone-co-vinyl laurate) may be a delivery system to the spleen

Otto Von Guericke University - Recommendations are reported for anesthesia during laparoscopic colonic surgery

PARI Aerosol Research Institute - Pharma company granted Orphan Medicial designation for inhaled cyclosporine

PDI, Inc. - Healthcare sales and marketing company acquires Pharmakon, L.L.C. assets

PRA International - Research organization taps Walsh to head quality and process management

PacificDental Benefits, Inc. - Dental benefits organization partner with Fidelity Security Life

Paul Ehrlich Institute - Prothrombin is a thrombogenic agent in PCCs

PediaMed - Children's health company president authors chapter of pharma industry book

Pfizer Inc. - Study shows DETROL LA effectively treats overactive bladder symptoms

PhDx Systems, Inc. - Medical outcomes technology provider hires VP sales and marketing

Phase Forward - Data management solutions announces underwriters exercised option

Phenomix Corporation - Drug discovery company appoints vice president of clinical development

Politecnico di Turin - Muscle fiber conduction velocity can be assessed with surface EMG signals

Princeton University - U.S. government funds center for quantitative biology

Protedyne Corporation - Laboratory automation supplier adds to board of directors

Queens University of Belfast - Anti-sized reed bed system is effective for animal wastewater treatment

Queensland Institute of Medical Research - Scabies is more than just an irritation

Rizzoli Orthopedic Institutes - Actin and zyxin mediate the work of CD99 in Ewing sarcoma

Roche - Natural peptide could play pivotal role in fight against autoimmune diseases

SGDP Centre, London - Microarrays suitable for analyzing X-linked gene expression

SIGA Technologies, Inc. - SIGA announces receipt of $12 million in NIH funding for biodefense

SRI International - Plexus and research institute partner to bring new products to market

San Antonio Orthopedic Group - Arthroscopic repair of HAGL lesion reviewed

San Camillo Hospital, Rome - Outcome of chest pain therapy for diabetics compared with nondiabetics

San Carlos University Hospital, Madrid - Impact of GP Ia gene T allele on clopidogrel efficacy determined

Sanofi-Synthelabo - Birth of third largest pharma company announced

Seattle Genetics, Inc. - Genetics-focused company gets orphan drug designation for multiple myeloma drug

Seoul National University - A novel bioactive and degradable bone substitute may have clinical application

Seoul National University - First-line laparoscopic surgery feasible for biliary-enteric fistula

Service Employees International Union Locals 250 - Registered nurses planned to shut down hospital in protest

Siemens Medical Solutions - FDA approves PMA for MAMMOMAT NovationDR

Sirtex Medical Ltd - Oncology-focused company progresses with Medicare coverage of device in U.S.

Smithsonian Tropical Research Institute - Processing of wild cereal grains revealed by starch grain analysis

Society of Gynecologic Oncologists - Care for terminally ill patients often depends on doctors' personal beliefs

Solucient - Healthcare business intelligence company names M.J. Bates information officer

Southwest College Research Institute - Homeopathic treatment found effective in relieving allergy symptoms

St. Jude Medical - Resynchronizing heart lead approved for E.U. sales, pacemaker approved by USFDA

St. Vincents Institute Med Research, Fitzroy - Glycoprotein E2 has mechanistic features in common with class II fusion proteins

Standard Insurance Company - Kevin Rainwater named director of retirement accounts for eastern U.S.

Stanford University Medical Center - The new deligotyping technique quickly detects microbial polymorphisms

State University of Ghent - MM-9 may be therapeutic target for healing quality after sinus surgery

SynCardia Systems, Inc. - Study finds heart transplant device reduces mortality in critically ill patients

Synovis Life Technologies, Inc. - Medical device company receives two U.S. patents for stylets delivery system

Synthematix, Inc. - Chemistry management software system for chemical library planning introduced

Technion Israel Institute Technology - Correlation of cyclophosphamide-induced neutropenia studied

Technion-Israel Institute of Technology - Neutralizing p28 subunit of IL-27 suppresses adjuvant-induced arthritis

Teikyo University - Estrogen uses cyclin D2 to stimulate keratinocyte growth

Tel Aviv-Sourasky Medical Center - Pulse pressure does not appear to be affected by early PDA closure

Texas Hospital Association - Texas hospitals see liability costs drop due to medical reforms, study shows

Texas Tech University - New concepts of physiology in obese patients reviewed

The Science Center - Philadelphia center promotes support for entreprenurial technology businesses

ThermoGenesis Corp. - BioArchive system chosen for the new M.D. Anderson Cord Blood Stem Cell Bank

Tiens Biotech Group Inc. - Biotech group reports consolidated net income up for 6 months ending June 30

Time Warner Telecom - Telecom company installs Ethernet data, Internet services for Florida hospital

Tokai University - p63 gene plays role in esophageal squamous cell carcinoma development

Tokyo Medical & Dental University - Peptide antigen plays role in inducing Streptococcus mutans antibodies

Tri-Service General Hospital, Taipei - Intrathecal IL-1beta activates iNOS-NO cascade in rats

Trinity Mother Frances Hospital, Tyler - Length of pulmonary artery introducer insufficient in obese patient

Tsing Hua University, Beijing - Structural basis proposed for coronavirus-mediated membrane fusion

Tufts University - Integrative and conjugative elements shape bacterial genetics

U.S. Centers for Disease Control & Prevention - Diabetes reduces quality of life in older adults

U.S. Centers for Disease Control & Prevention - Drinking alcohol increases risk for fighting and injuries in adolescents

U.S. Food & Drug Administration - Nivalenol induces benign and malignant tumors in mice

U.S. National Cancer Institute - Fetal alloantigen recognition may help reduce vertical transmission of viruses

U.S. National Institutes of Health - NIH releases research strategy to fight obesity epidemic

U.S. Washington State Department of Health - Cluster of male breast cancer linked to electromagnetic field exposure

Univ. of California, Irvine - Prenatal corticosteroid exposure suppresses HPA response in premature babies

Univ. of California, Los Angeles - Minorities worry health system won't respond fairly in a bioterrorist event

Univ. of California, San Francisco - Zoledronic acid halts disease progression in mice

University College of North Wales - ED50 values for praziquantel in Schistosoma mansoni determined

University Hospital Henri-Mondor, Creteil - Angioplasty can enable successful weaning from mechanical ventilation

University Hospital, Romania - Prevalence of bacterial meningitis among children in Romania reported

University Zurich Hospital - Genes induced by GDNF overproduction of neuronal progenitor cells characterized

University of Barcelona - Mycophenolate mofetil and HAART delays viral load rebound in HIV infection

University of Bonn - Cannabinoids effective against cachexia-anorexia syndrome in HIV patients

University of British Columbia - Multidrug-resistant tuberculosis treated successfully after liver transplant

University of California San Diego -  G. lamblia encystation dependent on novel transglutaminase activity

University of California, Davis - 15S-hydroxyeicosatrienoic acid may suppress prostate tumor growth

University of California, Irvine - Signaling pathway may be mediated by mpygo2

University of Chieti - Independent component analysis reconstructs fetal cardiac activity

University of Connecticut - Memory CD8 T cells are fully functional in the absence of CD4 T cells

University of Copenhagen - CCL2 and CCR2 may have a limited role in early active multiple sclerosis

University of Dublin - Genes regulated by S. typhimurium Fis cataloged

University of Florence - Thoracentesis is a less-invasive neonatal approach

University of Freiburg - Promising new anticoagulant offers fibrin-targeted factor Xa inhibition

University of Gdansk - Divergent hepatitis B virus genotypes in Poland reflect migratory events

University of Geneva - Study uncovers potential role of C21orf80 in pathogenesis of Down syndrome

University of Giessen - Small interfering RNAs silence disease-related genes

University of Gothenburg - Rat model is useful to study premenstrual irritability

University of Haifa, Tivon - Chironomid egg masses natural reservoir of V. cholerae non-O1 and non-O139

University of Helsinki - Adenovirus could aid local and systemic treatment of resistant disease

University of Helsinki - Protein expressed in tobacco inhibits enterotoxigenic E. coli binding

University of Illinois - College of nursing to expand primary care for mentally ill

University of Innsbruck Hospital - Sternal osteomyelitis reported after percutaneous coronary artery stenting

University of Manchester - Gelling pectin formulations show promise for paracetamol delivery

University of Massachusetts - Cross-reactivity among hantaviruses investigated

University of Munich - Suppressor of cytokine signaling proteins keep interferon from treating HCV

University of New South Wales - Enfuvirtide long-term HIV therapy has few side effects

University of New South Wales - Implantable electrodes may make prosthetic vision possible

University of Nijmegen - Tumor VEGF levels can't predict the value of adjuvant breast cancer therapy

University of Nottingham - Method to estimate threshold parameter R* reported

University of Oviedo - Perirenal fat diameter early predictor of HAART-associated lipodystrophy

University of Queensland - Best size descriptor to use for pharmacokinetic studies in obese discussed

University of Regensburg - Computer assistance improves postoperative leg alignment

University of San Diego - Some symptoms from diffuse electrical injury cannot be explained

University of Southampton - Susceptibility to respiratory disease linked to weight gain in early infancy

University of St. Etienne - Heart-rate increment is a simple and inexpensive screening tool for OSAHS

University of Succubi - Calcium-phosphate-hybridized tendon helps healing of tendon-bone insertion

University of Texas - 'Non-take' responses in adults vaccinated with smallpox reported

University of Texas - Desmin-related cardiomyopathy in transgenic mice: A cardiac amyloidosis

University of Texas SW Medical Center - Alleles contribute to low HDL cholesterol

University of Tokyo - Medaka mutations provide clues to molecular mechanisms of a functional liver.

University of Tokyo - Xantivin antagonizes EGF-CFC genes to disrupt nodal signaling

University of Toronto - The KCNQ1OT1 promoter is key to the genetic imprinting of chromosome 11p15.5

University of Tubingen - Nested multiplex polymerase chain reaction detects human papillomavirus DNA

University of Udine - BRCA2 mutations may be associated with primary cancer of the fallopian tube

University of Ulm - Researchers develop a kinematic knee-joint coordinate system

University of Vienna - Blue-field entoptic assay can measure LPS-induced microvascular leukocytosis

University of Wisconsin - Novel mAb may facilitate purification of TATA-binding protein

Valera Pharmaceuticals - Pharmaceutical company raises $11.5 million that includes new and existing investors

Vaso Active Pharmaceuticals - Pharmaceuticals company, chief executive officer settle with the SEC

Vejle Hospital - Ultrasonographic-guided needle marks rotator cuff calcium deposits

Vertical Health Solutions, Inc. - Maker of animal health products reports second quarter results

Wachovia Corporation - Group invests $20 million in kidney dialysis company, offers more for growth

Wageningen University - PPAR-alpha governs glycerol metabolism

Waters Instruments, Inc. - Instruments company establishes award for advancements in organ preservation

Weight Loss - Study analyzes very low-fat, high monounsaturated fat diets in overweight women

West Haven VA Healthcare Systems - HCV coinfection associated with higher risk of diabetes in HAART era

West Virginia University - Dual activities cause SU5416 to increase ovarian cancer chemosensitivity

XTL Biopharmaceuticals Ltd - Phase 2a trials reopened as U.S. FDA, pharmaceutical company reach agreement

Xenotope Diagnostics, Inc. - New, rapid assay for detection of T. vaginalis performs well in study

Yale University - Serum procalcitonin more accurate than CRP as marker of bacterial infection

Zhejiang University - Transgenic potato expressing bronchitis virus protein developed

eResearchTechnology, Inc. - Japanese operation awards studies for cardiac safety monitoring

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