Juntendo University, Tokyo
Parkin and alpha-synuclein govern dopaminergic metabolism and cell death
Published in Pharma Investments, Ventures and Law Weekly, July 17th, 2005
"Parkin, a product of the gene responsible for autosomal recessive juvenile parkinsonism, (AR-JP), is an important player in the pathogenic process of Parkinson disease (PD). Despite numerous studies including search for the substrate of parkin as an E3 ubiquitin-protein ligase, the mechanism by which loss-of-function of parkin induces selective dopaminergic neuronal death remains unclear," researchers in Japan report.
"Related to this issue, here we show that antisense knockdown of parkin causes apoptotic cell death of human dopaminergic SH-SY5Y cells associated with caspase...
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