Tohoku University

Hrs examined, preventative role in protein degradation defined

Published in Pharma Investments, Ventures and Law Weekly, July 17th, 2005

According to recently published research from Japan, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecules (STAMs).

"The degradation and sorting of cytoplasmic and cell-surface proteins are crucial steps in the control of cellular functions. We previously identified three mammalian Vps (vacuolar protein sorting) proteins, Hrs and STAM1 and -2, which are tyrosine-phosphorylated upon cytokine/growth factor stimulation," wrote H. Kobayashi and colleagues, Tohoku University.

"Hrs and the...

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Source: Pharma Investments, Ventures and Law Weekly (2005-07-17)

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