Yale University
Visual cortex analyzed, calcineurin-reversible block of plasiticity revealed
Published in Pharma Investments, Ventures and Law Weekly, August 7th, 2005
"Numerous protein kinases have been implicated in visual cortex plasticity, but the role of serine/threonine protein phosphatases has not yet been established. Calcineurin, the only known Ca2+/calmodulin-activated protein phosphatase in the brain, has been identified as a molecular constraint on synaptic plasticity in the hippocampus and on memory," wrote Y. Yang and colleagues, Yale University.
"Using transgenic mice overexpressing calcineurin inducibly in forebrain neurons, we now provide...
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