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National University of Singapore

Isothiocyanates induced nitric oxide and prostaglandins in Raw 264.7 macrophages

Published in Pharma Investments, Ventures and Law Weekly, August 7th, 2005

Researchers claimed that isothiocyanates (ITCs) induced the production of nitric oxide (NO) and prostaglandins (PGE) in Raw 264.7 macrophages.

"Beta-phenylethyl (PEITC) and 8-methylsulphinyloctyl isothiocyanates (MSO) represent two phytochemical constituents present in watercress Rorippa nasturtium aquaticum, with known chemo-preventative properties," scientists reported in the journal Nitric Oxide: Biology and Chemistry/Official Journal of the Nitric Oxide Society.

"In the present investigation, we examined whether PEITC and MSO could modulate the inflammatory response of Raw 264.7 macrophages to bacterial lipopolysaccharide (LPS) by...

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