University Children's Hospital, Wurzburg
Angiogenic homeostasis falters in placentas with chorioamnionitis
Published in Pharma Investments, Ventures and Law Weekly, November 6th, 2005
"Chorioamnionitis and funisitis are associated with neonatal morbidity and mortality. We hypothesized that chorioamnionitis may stress fetal endothelium, activate proinflammatory gene transcription, and affect angiogenic homeostasis in fetal capillaries," scientists in Germany report.
"Placentas from preterm infants were stained for heat-shock protein 70, nuclear factor-kappa B, hypoxia-inducible factor-1 alpha, and vascular endothelial growth factor (VEGF). VEGF receptors (VEGF-R) 1 and 2 as well as the receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology...
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