Published in Pharma Investments, Ventures and Law Weekly, November 13th, 2005
"Radial glia are integral components of the developing neocortex. During corticogenesis, they form an important scaffold for neurons migrating into the cortical plate," wrote M. Gierdalski and colleagues, Uniformed Service University of Health Science.
"Recent attention has focused on NRG1, acting through erbB receptors, in maintaining their morphology. We developed a model of developmental radial glial disruption by delivering an antimitotic [methylazoxy methanol (MAM)] to pregnant ferrets on embryonic day 24 (E24).
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