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Uniformed Service University of Health Science, Bethesda

Endogenous neuregulin restores radial glia in a model of cortical dysplasia

Published in Pharma Investments, Ventures and Law Weekly, November 13th, 2005

According to a study from the United States, endogenous neuregulin (NRG1) restores radial glia in a model of cortical dysplasia.

"Radial glia are integral components of the developing neocortex. During corticogenesis, they form an important scaffold for neurons migrating into the cortical plate," wrote M. Gierdalski and colleagues, Uniformed Service University of Health Science.

"Recent attention has focused on NRG1, acting through erbB receptors, in maintaining their morphology. We developed a model of developmental radial glial disruption by delivering an antimitotic [methylazoxy methanol (MAM)] to pregnant ferrets on embryonic day 24 (E24).

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