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Medical College of Wisconsin

Antibody response to receptor binding domain of botulinum serotypes examined

Published in Pharma Investments, Ventures and Law Weekly, November 20th, 2005

Scientists characterize the antibody response to the receptor binding domain of botulinum neurotoxin serotypes A and E in a recent issue of Infection and Immunity.

According to a study from the United States, "Clostridium botulinum neurotoxins (BoNTs) are the most toxic proteins for humans. The current clostridial-derived vaccines against BoNT intoxication have limitations including production and accessibility. Conditions were established to express the soluble receptor binding domain (heavy-chain receptor [HCR]) of BoNT serotypes A and E in Escherichia coli."

"Sera isolated from mice and rabbits immunized with recombinant...

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