Published in Pharma Investments, Ventures and Law Weekly, April 2nd, 2006
"Since the 1980s, the occurrence of pertussis cases in developed countries has increased and shifted towards older age groups. This resurgence follows 30 years of intense mass vaccination, and has been attributed primarily to three factors: more effective diagnosis of the disease, waning of vaccine-induced immunity, and loss of vaccine efficacy due to the emergence of new Bordetella pertussis strains. Here we develop and analyze a mathematical model to assess the plausibility of these hypotheses," investigators in Portugal report.
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