Karolinska University Hospital, Stockholm, Sweden
Angiomotin isoforms affect tube formation by controlling cell migration and cell shape
Published in Pharma Investments, Ventures and Law Weekly, July 9th, 2006
"Angiomotin, an 80 kDa protein expressed in endothelial cells, promotes cell migration and invasion, and stabilizes tube formation in vitro. Angiomotin belongs to a new protein family with two additional members, Amot1-1 and Amot1-2, which are characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs," investigators in Sweden explained.
"Here, we report the identification of a 130 kDa splice isoform of angiomotin that is expressed in different cell types including vascular endothelial cells, as well as cytotrophoblasts of the placenta....
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