INSERM U817, France
Modified adenovirus vector targeting CD21 improves gene delivery to B lymphocytes
Published in Pharma Investments, Ventures and Law Weekly, September 24th, 2006
According to a report from France, "Gene transfer by adenoviruses, which are widely used for gene therapy, may provide an alternative approach to treatment of several hematopoietic malignancies. However, a major limitation of adenovirus 5-based gene therapy lies in the natural tropism of the virus for the widely expressed hCAR receptor. The efficacy of adenoviral vectors could be improved if viral vectors that exhibit tissue-specific gene delivery were developed."
"For efficient gene transfer it is essential that every step from binding of virus to target cells to...
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