Ludwig Institute for Cancer Research, Brazil
Acute lymphoblastic leukemia prognosticated by CALCA promoter hypermethylation
Published in Pharma Investments, Ventures and Law Weekly, September 24th, 2006
According to recent research from Brazil, "Promoter hypermethylation occurs early in leukemogenesis and seems to be associated with poor prognosis in ALL. The methylation status of the promoter region of 6 genes was analyzed in 71 children with ALL using methylation specific PCR (MSP)."
"CALCA and E-cadherin (CDH1) were the most frequently methylated genes in this group of patients. Considering the patients with CNS infiltration, the estimated 2-year overall survival (OS) was 20%...
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