Henry Ford Hospital, Detroit, U.S.
New findings from the United States and Sweden in the area of neurology described
Published in Pharma Investments, Ventures and Law Weekly, October 1st, 2006
Study 1: Inhibition of phosphodiesterase type 5 (PDE5) activity by sildenafil augments neurogenesis in the subventricular zone (SVZ) of aged ischemic rats.
"Increasing age decreases the number of new neurons in the dentate gyrus and the subventricular zone. Sildenafil, a phosphodiesterase type 5 inhibitor, enhances neurogenesis in young rats," scientists in the United States reported.
"The present study tested the hypothesis that sildenafil augments neurogenesis in aged rats after focal cerebral ischemia. Nonischemic aged (18 months, n=6) Wistar rats...
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