Drug Discovery

Research conducted at University of Oviedo has updated our knowledge about drug discovery

Published in Pharma Investments, Ventures and Law Weekly, December 31st, 2006

Investigators publish new data in the report "The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives. Members of the aureolic acid family are tricyclic polyketides with antitumor activity which are produced by different streptomycete species. These members are glycosylated compounds with two oligosaccharide chains of variable sugar length," scientists in Oviedo, Spain report.

"They interact with the DNA minor groove in high-GC-content regions in a nonintercalative way and with a requirement for magnesium ions. Mithramycin and chromomycins are the most representative members of the family, mithramycin being used as...

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Source: Pharma Investments, Ventures and Law Weekly (2006-12-31)

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