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Chromatography

Research from J. Zhang and co-researchers yields new findings on chromatography

Published in Pharma Investments, Ventures and Law Weekly, January 13th, 2008

"Sirolimus, an effective immunosuppressive agent, is used for drug eluting stents. During stent development, an analytical method for the determination of sirolimus in tissue needs to be established," scientists in the United States report.

"Normally, tissue samples are homogenized and then analyzed against the calibration standards prepared in a tissue homogenate. This approach provides insufficient control of the homogenization process. In this paper, tissue quality control samples were introduced for the optimization of the homogenization process during method development, but also allowance for the performance evaluation of the entire analytical process. In...

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