Monoclonal Antibodies
New monoclonal antibodies study results reported from M. Matignon et al
Published in Pharma Investments, Ventures and Law Weekly, January 20th, 2008
According to recent research published in the journal Transplantation Proceedings, "There is no optimal desensitization protocol for cadaveric renal transplant recipients who display high levels of donor-specific alloantibodies as defined by a positive T- or B-cell cytotoxic crossmatch. We used anti-CD20 monoclonal antibodies (Rituximab) to try to prevent antibody-mediated rejection in three crossmatch-positive renal transplants recipients (standard and sensitized techniques)."
"The three patients received a first, second, or third cadaveric donor renal transplant. Patient one had an historical positive T- and B-cell cytotoxicity crossmatch: negative T- and...
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