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Acute Promyelocytic Leukemia
Recent findings in acute promyelocytic leukemia described by F. Guidez and colleagues
March 2nd, 2008
According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "Leukemia-associated chimeric oncoproteins often act as transcriptional repressors, targeting promoters of master genes involved in hematopoiesis. We show that CRABPI (encoding cellular retinoic acid binding protein I) is a target of PLZF, which is fused to RAR alpha by the t(11;17)(q23;q21) translocation associated with retinoic acid (RA)resistant acute promyelocytic leukemia (APL)." "PLZF represses the CRABP1 locus through propagation of chromatin condensation from a remote intronic binding element culminating in silencing of...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-02)
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