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Adenovirus
Reports summarize adenovirus study results from AstraZeneca
March 2nd, 2008
According to recent research from Sweden, "Previous studies have indicated that the hyperlipidemia and gene expression changes induced by a short-term high-fat diet (HFD) are mediated through the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1 beta, and that in vitro both PGC-1 beta and PGC-1 alpha increase PPAR alpha-mediated transcriptional activities. Here, we examined the in vivo effects of these two coactivators in potentiating the lipid lowering properties of the PPAR alpha agonist Wy14,643 (Wy)." "C57BL/6 mice were fed chow or HFD and transduced with adenoviruses encoding PGC-1 alpha or PGC-1 beta. On chow, hepatic PGC-1 beta overexpression...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-02)
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