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Adenovirus
Research from St. Louis University broadens understanding of adenovirus
March 2nd, 2008
According to recent research from the United States, "A short open reading frame named the ''U exon,'' located on the adenovirus (Ad) I-strand (for leftward transcription) between the early E3 region and the fiber gene, is conserved in mastadenoviruses. We have observed that Ad5 mutants with large deletions in E3 that infringe on the U exon display a mild growth defect, as well as an aberrant Ad E2 DNA-binding protein (DBP) intranuclear localization pattern and an apparent failure to organize replication centers during late infection." "Mutants in which the U exon DNA is reconstructed have a reversed phenotype. Chow et al. (L. T. Chow et al., J. Mol. Biol. 134:265-303,...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-02)
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