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Adenovirus
Studies from Center for Biologics Evaluation and Research in the area of adenovirus described
March 9th, 2008
Investigators publish new data in the report 'A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells.' According to a study from the United States, "Kupffer cells are a major barrier to systemic adenovirus (Ad) gene therapy because they rapidly and efficiently clear virions from the circulation. The lack of a straightforward quantitative technique for selectively measuring uptake of Ad by Kupffer cells has made it difficult to study the mechanisms by which they recognize Ad." "A new method was developed that relies on immunofluorescent detection of Ad within Kupffer cells in mouse liver sections, followed by confocal microscopy and...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-09)
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