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Alcoholism
Attention! The increased oxidative stress in decompensated cirrhotic patients
March 16th, 2008
Oxidative stress describes the state level of oxidative damage in a cell, tissue or organ, caused by reactive oxygen species. Alcohol induces oxidative stress in the liver resulting in an imbalance between oxidants and anti-oxidants. Increased reactive oxygen species (ROS) production and glutathione (GSH) depletion, lead to abnormal breakdown of fat molecules (i.e., lipid peroxidation). This complex process results in the formation of toxic compounds and may contribute to the pathogenesis of alcoholic liver injury. A research article to be published on January 14, 2008 in the World Journal of Gastroenterology addresses this question. The study was designed to study...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-16)
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