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Algorithms
New algorithms study findings have been reported by researchers at Pitie-Salpetriere Hospital, Department of Virology
March 16th, 2008
Researchers detail in 'Comparison of two genotypic algorithms to determine HIV-1 tropism,' new data in algorithms. "One or both of two co-receptors, CCR5 (R5) and CXCR4 (X4), are used by HIV-1 to enter into host cells. The glycoprotein 120 (gp120) V3 sequence is correlated with the R5 and X4 phenotype," investigators in France report. "CCR5 inhibitors are specifically active against R5 viruses, suggesting the need to determine tropism before the use of these antagonists. A comparison of the position-specific scoring matrices (PSSM) and Geno2pheno algorithms based on the V3 loop gp120 sequences and previously described to be correlated to the R5 or X4 phenotype was...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-16)
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