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Acute Cystitis Cell Biology
Reports from Washington University advance knowledge in acute cystitis cell biology
March 23rd, 2008
Data detailed in 'LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis' have been presented. "Uropathogenic Escherichia coli (UPEC) contain multiple horizontally acquired pathogenicity-associated islands (PAI) implicated in the pathogenesis of urinary tract infection. In a murine model of cystitis, type 1 pili-mediated bladder epithelial invasion and intracellular proliferation are key events associated with UPEC virulence," scientists in the United States report. "In this study, we examined the mechanisms by which a conserved PAI contributes to UPEC pathogenesis in acute cystitis. In the human UPEC strain UTI89,...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-23)
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