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Acute Lymphoblastic Leukemia
Studies from M. Vaskova et al further understanding of acute lymphoblastic leukemia
March 23rd, 2008
According to recent research from Prague, Czech Republic, "The expression of CD27 and CD44 correlate with the genotype of B-precursor acute lymphoblastic leukemia (ALL). Based on the expression of these antigens, we identified counterparts of TEL/AML1(pos) and TEL/AML1(neg) leukemic cells in nonmalignant bone marrow." "Although CD27 is known as a marker of mature memory B cells, we recently showed that CD27 is also expressed by malignant and nonmalignant B precursors. Here, we show that CD27 and CD44 delineate stages of B-precursor development. Well-established differentiation markers showed that the developmental sequence starts from undetermined progenitors,...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-23)
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