Pharma Investments, Ventures & Law Weekly
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Adenoma
New adenoma data have been reported by M. Tzouvala and co-authors
March 23rd, 2008
"An imbalance between apoptotic and proliferative processes is believed to underlie colorectal neoplasia. We evaluated the expression of bcl-2, p53, mdm2 proteins, and apoptosis in colorectal neoplasms, as well as their correlation with clinico-pathological parameters, using image analysis," scientists in Athens, Greece report. "Biopsies from 46 colorectal cancers, 121 adenomas, and 25 controls were studied using monoclonal antibodies against p53, bcl-2, mdm2 and the terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL) method for apoptosis. P53 and bcl2 protein expression was higher in adenomas >= 1 cm (P < 0.03) and tubulovillous-villous...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-23)
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