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Adverse Drug Reactions
New adverse drug reactions study results reported from M. Yoshida et al
March 23rd, 2008
According to recent research published in the journal Pharmacoepidemiology and Drug Safety, " Grapefruit juice has been found to interact with calcium channel blockers (CCB). This interaction is due to certain nutrients found in grapefruit juice that block the activity of cytochrome P-450 (CYP) 3A4 in the small intestine and liver." "Inhibition of CYP3A4 markedly increases bioavailability and increases the risk of an adverse drug reaction (ADR). Many drugs are known to have CYP3A4-blocking activity. This study was performed to investigate whether the concomitant use of a CYP3A4 inhibitor and a CCB in hypertensive patients results in an elevated incidence of ADRs....
Source: Pharma Investments, Ventures & Law Weekly (2008-03-23)
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