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Acute Myeloid Leukemia
East Carolina University details research in acute myeloid leukemia
March 30th, 2008
"HMG-CoA Reductase inhibitors (statins) induce apoptosis in acute myeloid leukemia (AML) cells in vitro; however, the concentrations associated with cell death in AML cells are higher than those clinically tolerated during prolonged therapy. We therefore wished to determine whether short exposures to lovastatin might induce cell death in AML cells at clinically attainable concentrations," investigators in the United States report. "The time and concentration dependence of HL60 and U937 cells was determined and showed that cell death was delayed. IC50 values and IC90 values determined on day 6 suggested that the sensitivity of AML cells to statins may occur at lower...
Source: Pharma Investments, Ventures & Law Weekly (2008-03-30)
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