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Acute Myeloid Leukemia
New acute myeloid leukemia findings from L. Lu and co-authors described
March 30th, 2008
"Neuropilin-1 (NRP-1) is a novel receptor of vascular endothelial growth factor (VEGF) and expressed in endothelial cells and tumor cells. The role of NRP-1 in the growth and progression of leukemia is unknown," investigators in Tianjin, People's Republic of China report. "Here we studied the mRNA expression and effect of NRP-1 in leukemic cells. Our results showed that NRP-1 mRNA was expressed in six of seven leukemic cell lines and primary leukemias derived from all 24 patients with acute myeloid leukemia (AML). Reduced NRP-1 expression by RNA interference led to a decrease of VEGF-mediated mitogenic and migration responses in acute myeloid leukemic cell line HEL....
Source: Pharma Investments, Ventures & Law Weekly (2008-03-30)
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