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Pharma Investments, Ventures & Law Weekly

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Adenovirus



Study data from University of Gottingen, Heart Center update understanding of adenovirus



April 6th, 2008

According to recent research from Germany, "Recovery of intracellular Ca transients and fractional shortening during late phase acidosis are suggested to be associated with CaMKII-dependent processes of which phospholamban (PLB) phosphorylation may play an important role. To test whether increased expression levels of CaMKII may further enhance recovery, we investigated myocytes from CaMKII delta(C) transgenic (TG) mice (cytosolic localized CaMKII) having heart failure vs. wildtype littermates (WT)."

"Furthermore, mouse and rabbit myocytes overexpressing CaMI:I delta(C) using adenovirus-mediated gene transfer (vs. LacZ control) were investigated. Fractional shortening...


Source: Pharma Investments, Ventures & Law Weekly (2008-04-06)

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