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Acute Promyelocytic Leukemia Genetics
Researchers from University of Munster, Center For Clinical Research publish findings in acute promyelocytic leukemia genetics
April 13th, 2008
Current study results from the report, 'Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip,' have been published. According to a study from Munster, Germany, "The translocation t(15;17) generates the chimeric PML-RARalpha transcription factor that is the initiating event of acute promyelocytic leukemia. A global view of PML-RARalpha transcriptional functions was obtained by genome-wide binding and chromatin modification analyses combined with genome-wide expression data." "Chromatin immunoprecipitation (ChIP)-chip experiments identified 372 direct genomic PML-RARalpha targets. A subset of these was...
Source: Pharma Investments, Ventures & Law Weekly (2008-04-13)
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