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Adverse Drug Reactions
New findings reported from D.A. Flockhart and co-authors describe advances in adverse drug reactions
April 13th, 2008
According to recent research published in the journal Genetics in Medicine, "Warfarin (Coumadin) is a potent drug that when used judiciously and monitored closely, leads to substantial reductions in morbidity and mortality from thromboembolic events. However, even with careful monitoring, initiation of warfarin dosing is associated with highly variable responses between individuals and challenges achieving and maintaining levels within the narrow therapeutic range that can lead to adverse drug events." "Variants of two genes, CYP2C9 and VKORC1, account for 30-50% of the variability in dosing of warfarin; thus, many believe that testing of these genes will aid in...
Source: Pharma Investments, Ventures & Law Weekly (2008-04-13)
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