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Acute Myelogenous Leukemia
Research from University of Bologna yields new findings on acute myelogenous leukemia
April 20th, 2008
"The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase (PI3K), is known to play an important role in antiapoptotic signaling and has been implicated in the aggressiveness of a number of different human cancers including acute myelogenous leukemia (AML). We have investigated the therapeutic potential of the novel Akt inhibitor, perifosine, on human AML cells," investigators in Bologna, Italy report. "Perifosine is a synthetic alkylphospholipid, a new class of antitumor agents, which target plasma membrane and inhibit signal transduction networks. Perifosine was tested on THP-1 and MV 4-11 cell lines, as well as primary leukemia cells....
Source: Pharma Investments, Ventures & Law Weekly (2008-04-20)
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