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Acute Lymphoblastic Leukemia
Data on acute lymphoblastic leukemia described by V. Ong et al
April 27th, 2008
According to a study from Randwick, Australia, "The microtubule-depolymerizing drug, vincristine, is effective in the treatment of acute lymphoblastic leukemia (ALL). Although vincristine resistance mechanisms have been extensively characterized in cell lines, their clinical relevance is poorly understood." "The aim of the current study was to define clinically relevant mechanisms of vincristine resistance in a panel of childhood ALL xenografts established in immune-deficient (nonobese diabetic/severe combined immunodeficient) mice. We also studied two independent xenograft sublines that were selected by in vivo vincristine exposure. In vitro vincristine sensitivity...
Source: Pharma Investments, Ventures & Law Weekly (2008-04-27)
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