Pharma Investments, Ventures & Law Weekly
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Aggression
Study data from University of Copenhagen update knowledge of aggression
April 27th, 2008
"The Gal alpha 1-3Gal beta 1-4GlcNAc epitope is the key antigen in the hyperacute rejection of pig-to-man xenotransplantation. In the alpha-1,3-galactosyltransferase knockout (alpha-1,3GT-KO) mouse - a model for xenograft donor pigs - a targeted mutation of the alpha-1,3 galactosyltransferase gene (Ggta1) has been constructed," investigators in Frederiksberg, Denmark report. "These mice are depleted of the carbohydrate antigen and besides the mice are also known to develop cortical cataracts. The present study aimed at evaluating the morphology and the degree of the cataract in a population of alpha-GT KO mice, its age of onset, its progression and the impact the...
Source: Pharma Investments, Ventures & Law Weekly (2008-04-27)
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