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Abdominal Aortic Aneurysm
Boehringer Ingelheim GmbH details research in abdominal aortic aneurysm
May 4th, 2008
According to a study from the United States, "Vessel wall inflammation and matrix destruction are critical to abdominal aortic aneurysm ( AAA) formation and rupture. We have previously shown that urokinase plasminogen activator (uPA) is highly expressed in experimental AAA and is essential for AAA formation and expansion." "In this study, we examined the effects of overexpression of a natural inhibitor of uPA, plasminogen activator inhibitor-1 (PAI-1), on the development of angiotensin (Ang) II-induced AAA in ApoE-deficient (ApoE (/) ) mice. Mice were treated with recombinant adenovirus containing either the human PAI-1 gene (Ad5. CMV. PAI-1) or the luciferase gene...
Source: Pharma Investments, Ventures & Law Weekly (2008-05-04)
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