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Addiction Medicine
Scientists at Duquesne University report research in addiction medicine
May 4th, 2008
"Pharmacological and behavioral studies indicate that binding of cocaine and the amphetamines by the dopamine transporter (DAT) protein is principally responsible for initiating the euphoria and addiction associated with these drugs. The lack of an X-ray crystal structure for the DAT or any other member of the neurotransmitter:sodium symporter (NSS) family has hindered understanding of psychostimulant recognition at the atomic level, structural information has been obtained largely from mutagenesis and biophysical studies," scientists in the United States report. "The recent publication of a crystal structure for the bacterial leucine transporter LeuT(Aa), a distantly...
Source: Pharma Investments, Ventures & Law Weekly (2008-05-04)
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