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Adenovirus
Research from St. Louis University in adenovirus provides new insights
May 4th, 2008
According to recent research from the United States, "The adenovirus E1A 243R oncoprotein encodes a potent transcription-repression function within the N-terminal 80 amino acids. Our proposed model of E1A repression predicts that E1A interacts with important cellular proteins on chromatin." "Consistent with this idea, we report here that E I A proteins from in vivo formaldehyde cross-linked 293 cells are closely associated with chromatin even after several stringent purification steps including double isopycnic CsCl density gradient centrifugation and size exclusion chromatography. Likewise, E I A proteins expressed from virus during productive infection of HeLa cells...
Source: Pharma Investments, Ventures & Law Weekly (2008-05-04)
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