Pharma Investments, Ventures & Law Weekly
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Aging
Studies from Ohio University provide new data on aging
May 4th, 2008
"Biological aging is an independent risk factor for many cardiovascular diseases; some are treated with beta-blockers that may protect dysfunctional endothelium during aging by increasing NO, decreasing ONOO-, and restoring NO/ONOO- balance. A nanotechnological approach was used to simultaneously monitor NO and ONOO- produced by a single aortic endothelial cell from Wistar-Kyoto rats of different ages. beta-blockers (metoprolol and atenolol) were administered 2 weeks before the animals were sacrificed," investigators in the United States report. "Nanosensors were placed near the endothelium, and calcium ionophore-stimulated NO and ONOO- release was measured. Endothelial...
Source: Pharma Investments, Ventures & Law Weekly (2008-05-04)
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