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African Trypanosomiasis
Research on african trypanosomiasis described by scientists at University of London, Queen Mary College
May 11th, 2008
According to a study from London, the United Kingdom, "The trypanocidal activity of the ODC (ornithine decarboxylase) inhibitor DFMO (difluoromethylornithine) has validated polyamine biosynthesis as a target for chemotherapy. As DFMO is one of only two drugs used to treat patients with late-stage African trypanosomiasis, the requirement for additional drug targets is paramount." "Here, we report the biochemical properties of TbSpSyn (Trypanosoma brucei spermidine synthase), the enzyme immediately downstream of ODC in this pathway. Recombinant TbSpSyn was purified and shown to catalyse the formation of spermidine from putrescine and dcSAM (decarboxylated...
Source: Pharma Investments, Ventures & Law Weekly (2008-05-11)
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