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Allergies
Studies from University of Nancy have provided new information about allergies
May 18th, 2008
"Tumor necrosis factor-a ( TNF-alpha) is released from mast cells via an immunoglobulin E (IgE)-dependent mechanism. The variant G> A at -308 of TNFA is part of an extended haplotype HLA-A1-B8-DR3-DQ2 and influences the gene expression," investigators in Nancy, France report. "We evaluated this variant in relation to IgE-mediated reactions to betalactams, in 427 subjects, including 167 cases and 260 age- and gender-paired controls. TNFA GG genotype was a significant independent predictor of the primary risk of betalactam allergy, concurrently with total IgE level, with an age- and sex-adjusted odds ratio estimated at 2.45 ( 95% confidence interval: 1.18-5.08, P =...
Source: Pharma Investments, Ventures & Law Weekly (2008-05-18)
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