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Alzheimer Disease Therapy
Studies from University of California, Department of Neurosciences update current data on Alzheimer disease therapy
May 18th, 2008
New investigation results, 'Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein,' are detailed in a study published in Journal of Biological Chemistry. "Elucidation of Abeta-lowering agents that inhibit processing of the wild-type (WT) beta-secretase amyloid precursor protein (APP) site, present in most Alzheimer disease (AD) patients, is a logical approach for improving memory deficit in AD. The cysteine protease inhibitors CA074Me and E64d were selected by inhibition of beta-secretase activity in regulated secretory vesicles...
Source: Pharma Investments, Ventures & Law Weekly (2008-05-18)
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