Pharma Investments, Ventures & Law Weekly
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Aneurysm
New research on aneurysm from Kyoto University, Medical Department summarized
May 18th, 2008
"The pathophysiology of cerebral aneurysms ( CAs) is linked to chronic inflammation and degradation of extracellular matrix in vascular walls. Because statins have protective effects on various vascular diseases independent of their lipid- lowering effects, we investigated the effect of simvastatin on CA progression," investigators in Kyoto, Japan report. "CAs were induced in Sprague- Dawley rats with or without oral administration of simvastatin. The size and media thickness of CAs was evaluated 3 months after aneurysm induction. Expression of macrophage chemoattractant protein- 1, vascular cell adhesion molecule- 1, endothelial nitric oxide synthase, interleukin- 1...
Source: Pharma Investments, Ventures & Law Weekly (2008-05-18)
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