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Acute Myeloid Leukemia
Reports from Kyorin University describe recent advances in acute myeloid leukemia
January 18th, 2009
According to a study from Shinkawa, Japan, "The p300 protein shows a striking homology with cyclic-AMP-response-element-binding-protein binding protein (CBP) and both proteins form a family of DNA-binding transcriptional coactivators/histone acetyltransferases. The authors, herein, report a therapy-related acute myeloid leukemia with MLL-p300 fusion gene." "Spectral karyotyping clarified that chromosome 11 is involved in complex t(1;22;11)(q44;q13;q23), and is fused to the chromosome 22, and direct sequencing revealed the fusion of exon 8 of MLL and exon 15 of p300 in this case. This is only the second reported case of leukemia with an MLL-p300 fusion gene, and the...
Source: Pharma Investments, Ventures & Law Weekly (2009-01-18)
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