Gene Therapy

Studies from T. Ota et al in the area of gene therapy described

Published in Pharma Investments, Ventures and Law Weekly, August 16th, 2009

"IgE plays a pivotal role in allergic reactions and asthma through its ability to bind to the mast cell FcR for IgE (Fc epsilon RI). Current therapies to suppress such reactions include passive treatment with neutralizing Abs to IgE that block its binding to Fc epsilon RI," scientists in the United States report.

"In theory, induction of immune tolerance in the B lymphocytes that carry IgE Ag receptors and give rise to IgE-secreting cells should provide longer term efficacy. However, recent data have suggested that such memory cells may lack cell surface IgE. Using a gene therapy approach, we show that a recombinant single-chain neutralizing anti-IgE could not only...

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Source: Pharma Investments, Ventures and Law Weekly (2009-08-16)

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