Herpesvirus

Findings from University of Nebraska provide new insights into herpesvirus

Published in Pharma Investments, Ventures and Law Weekly, October 25th, 2009

"Sensory neurons within trigeminal ganglia (TG) are the primary site for bovine herpesvirus 1 (BHV-1) latency. During latency, viral gene expression is restricted to the latency-related (LR) gene and the open reading frame ORF-E," scientists in the United States report.

"We previously constructed an LR mutant virus that expresses LR RNA but not any of the known LR proteins. In contrast to calves latently infected with wild-type (wt) BHV-1 or the LR rescued virus, the LR mutant virus does not reactivate from latency following dexamethasone (DEX) treatment. In this study, we demonstrated that bICP0, but not bICP4, transcripts were consistently detected in TG of calves...

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Source: Pharma Investments, Ventures and Law Weekly (2009-10-25)

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