Monoclonal Antibodies

Study results from R.L. Johnston and colleagues broaden understanding of monoclonal antibodies

Published in Pharma Investments, Ventures and Law Weekly, December 6th, 2009

"Anti-CTLA-4 antibodies are human monoclonal antibodies previously studied in the treatment of metastatic melanoma (MM). CTLA-4 is an inhibitory receptor on cytotoxic T cells, blockade of which will activate T cells allowing them to attack malignant cells," scientists in the United States report.

"Normal host cells may also be affected, and immune-mediated enterocolitis can occur. This is a prospective observational study on the use of corticosteroids and infliximab in the treatment of patients with immune-mediated colitis secondary to anti-CTLA-4 antibody treatment of MM. Five patients presented with colitis after medication administration. were treated with high-dose...

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Source: Pharma Investments, Ventures and Law Weekly (2009-12-06)

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